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Table of Content

    15 October 2023, Volume 8 Issue 10

    Anti-Tumor Effect and Mechanism of C-3 Extractive from Periplaneta americana on S180 Sarcoma-Bearing Mice

    Lu Li, He Xu, Zhang Yanju, Peng Fang
    2023, 8(10):  1-8. 
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    ObjectiveTo investigate the anti-tumor effect and mechanism of C-3 extractive from Periplaneta americana on S180 sarcoma-bearing mice. MethodsS180 sarcoma-bearing mice were randomly divided into model grouppositive control CTXgrouphigh-dosemedium-dose and low-dose C-3 groupsand a normal control groupwith 10 mice in each group. The pathological changes of tumor tissue in each group were observed after administrationand the tumor inhibition rate was calculated. ELISA kits were used to test the levels of vascular endothelial growth factorVEGFand telomeraseTEin serum. The expression of p53B-cell lymphoma 2Bcl-2), cysteinyl asparate specific protease-3Caspase-3), microvessel density MVDand cyclooxygenase-2COX-2protein in tumor tissue were detected by immunohistochemistry. ResultsThe tumor inhibition rates of CTX grouphigh-dosemedium-doseand low-dose C-3 groups were 85.71%55.71%44.28%34.28%respectively. The necrotic area of tumor tissue was obvious in high-dose and medium-dose C-3 groups. Compared with the model groupthe TE activity was decreased in high-dose C-3 groupP<0.05), and the expression of p53Bcl-2MVD and COX-2 in tumor tissues of high-dose and medium-dose C-3 groups were significantly decreasedP<0.01), while the Caspase-3 expression was significantly increasedP<0.01. ConclusionC-3 can significantly inhibit the growth of S180 sarcomaand its mechanism may be related to the reduction of TE activitythe decrease of p53Bcl-2MVDCOX-2 expressionand the increase of Caspase-3 expression in tumor tissue.

    Research on the Survey of Medicinal Plant Resources in Binchuan County Based on the Fourth National Survey of Chinese Materia Medica Resources

    Huang Bo, Zhang Huayan, Yang Xiujuan, Zhang Ping, He Yunchang,
    2023, 8(10):  9-15. 
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    ObjectiveBased on the Fourth National Survey of Chinese Materia Medica Resourcesthe speciesdistribution and cultivation of wild traditional Chinese medicine resources in Binchuan County were investigated. MethodsThe medicinal plants in Binchuan County were statistically analyzed through field sample surveyinterview surveycollection of plant specimens and reference to relevant literature. ResultsThere were 583 species of medicinal plants belonging to 388 genera in 101 families in this county. Among themthe dominant family of medicinal resources was Asteraceaefollowed by Leguminosae. There were relatively few key medicinal plants with large reserves. There were 22 kinds of medicinal plant which were mainly cultivated in this county. ConclusionBinchuan County is rich in wild medicinal plant resourcesso it is necessary to strengthen the protection of medicinal plant resources in this region and ensure their sustainable utilization during development and utilization.

    The Impact of Pharmaceutical Care Intervention on Medication Compliance and Efficacy in Hypertension Patients of Bai Ethnic Minority

    Li Xia , Dong Xiaowei, Qiu Lin, Yang Pihui, Dong Ying, Wang Qinggui, Gu Yun
    2023, 8(10):  16-20. 
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    ObjectiveTo investigate the impact of pharmaceutical care intervention on medication compliance and efficacy in hypertension patients of Bai ethnic minority. MethodsA total of 106 essential hypertension patients of Bai ethnic minority who were treated in the First Affiliated Hospital of Dali University from January to June 2020 were selected as study objectsand randomly divided into control group and intervention group. The control group received routine pharmaceutical careand the intervention group adopted the plan-do-check-actionPDCAcycle to carry out pharmaceutical care. The quality of life scoresblood pressure controlmedication compliance and incidence of adverse reactions were compared before and after intervention in both groups. ResultsAfter interventionthe scores of each dimension in the quality of life scale in the intervention group were significantly higher than those in the control groupand the systolic and diastolic blood pressure were significantly lower than those in the control groupwith statistical significanceP<0.01); the medication compliance rate in the intervention group was significantly higher than that in the control groupand the incidence of adverse drug reactions was significantly lower than that in the control groupwith statistical significanceP<0.01. ConclusionAdopting PDCA cycle to carry out pharmaceutical care can improve medication compliance of hypertension patients of Bai ethnic minority and help them better control blood pressure.

    The Inhibitory Activity of Pinus yunnanensis Pine Extract with Anti-HIV Activity against Human Coronavirus 229E

    Li Yafei, Shang Fangjian, Luo Chunyu, Shi Zhefang, Liu Qi,
    2023, 8(10):  21-26. 
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    ObjectiveTo evaluate the inhibitory activity of Pinus yunnanensis pine extractreferred to as "pine extract"with anti-HIV activity against human coronavirus HCoV-229E and preliminarily determine its target. MethodsA cell-cell fusion model and  model mediated by HCoV-229E S protein were constructed to detect the inhibitory activity of pine extract against HCoV-229E. Time-of-addition and time-of-removal experiments were performed to determine the target and the timing of action. ResultsPine extract could inhibit the cell-cell fusion mediated by HCoV-229E S proteinwith an IC50 of 0.136±0.010mg/mL. It effectively inhibited HCoV-229E infectionwith an IC50 of 0.069±0.015mg/mL. Time-of-removal and time-of-addition experiments showed that pine extract targeted the HCoV-229E S protein and acted in the early stage of infection1 h before); different concentrations of pine tower extracts have no significant toxicity to 293T and Huh-7 cells. ConclusionPine extract can target the HCoV-229E S protein and inhibit HCoV-229E infection in the early stagemaking it a safe candidate drug.

    Research on the Application of Gold Nanorods in the Detection of Circulating Antigens in Clonorchis sinensis Serum

    Chen Liping, Lian Xiaoli, Cai Zihan, Li Qian, Ouyang Tianzhao, Yang Yimei
    2023, 8(10):  27-33. 
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    ObjectiveTo study the detection effect of gold nanorods on early and low worm burden of Clonorchis sinensis. MethodsGold nanorods were labeled with different concentrations of thiolated Clonorchis sinensis-specific IgG antibodies. The absorption peaks of the gold nanorods were scanned using a UV spectrophotometer to observe the magnitude of the peak shift and determine the optimal labeling concentration. The gold nanorods labeled with the optimal concentration of antibodies were used to detect circulating antigens in rat serum with different infection degreesinfection timesand dilutions.  ResultsThe maximum peak shift was 20.0 nm when the gold nanorods were labeled with 20 μg/mL antibodies. The gold nanorods labeled with Clonorchis sinensis specific IgG antibodies could detect circulating antigens in rat serum at 310 17 and 31 d after infection with 50100 and 200 cercariaeas well as at a dilution of 1400. ConclusionGold nanorods labeled with Clonorchis sinensis specific IgG antibodies have significant advantages in the detection of early and low worm burden of Clonorchis sinensis.

    Efficacy Analysis of astroscopic Metal Titanium Clip Combined with Medical Adhesive in the Treatment of Gastric Fundal Varices

    Ma Mengxia, Tao Zhongyuan, Guo Shunhong, Zhao Chunping, Li Bowen, Zhang Qinyuan
    2023, 8(10):  34-37. 
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    ObjectiveTo investigate the clinical efficacy of gastroscopic metal titanium clip combined with medical adhesive in the treatment of gastric fundal varices. MethodsA retrospective analysis was performed on the medical records of 80 patients who underwent gastroscopic treatment for gastric fundal varices with medical adhesive at the Endoscopy Center of the First People's Hospital of Dali City from June 12020 to June 302021. The clinical efficacy and safety of the monotherapymonotherapy groupand metal titanium clip combined therapycombined groupwere compared. ResultsCompared with the monotherapy groupthe combined group had a significantly increased amount of medical adhesive usedwith a statistically significant differenceP<0.05. Howeverthe rebleeding rate between the two groups was only statistically significant at 3 months after surgeryP<0.05), while there was no statistically significant difference at other time pointsP>0.05. Additionallyno cases of ectopic embolism occurred during the 12-month follow-up period in both groups. ConclusionGastroscopic metal titanium clip combined with medical adhesive in the treatment of gastric fundal varices can reduce the rate of rebleeding and is a safe and effective treatment method.

    Selection of Approach for Laparoscopic Anatomic Left Hepatectomy

    Li Xiaoju, , Wang Xingru, , Xiong Liqiao, Wan Dandan, Liu Tianxi,
    2023, 8(10):  38-42. 
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    ObjectiveTo investigate the safety and feasibility of hepatic parenchymal approach in laparoscopic anatomic left hepatectomy. MethodsA retrospective analysis was conducted on the clinical data of 151 patients who underwent laparoscopic left hepatectomy for benign diseases at the Department of Hepatobiliary Surgerythe Second People's Hospital of Qujing City from August 2018 to August 2021. According to the different surgical approachesthe patients were divided into a modified group and a traditional group. The modified group used a liver parenchyma priority approach for liver resectionwhile the traditional group used a pedicle-first approach. The preoperative conditionssurgical resection scopeintraoperative conditionsand postoperative outcomes were compared between the two groups. ResultsThere were no statistically significant differencesP>0.05in preoperative and postoperative indicatorssurgical resection scopeand intraoperative blood loss between the two groups. The modified group had significantly shorter operation time and first porta hepatis clamping time compared to the traditional groupwith statistical significance P<0.05. ConclusionHepatic parenchyma priority approach is safe and feasible in laparoscopic left hepatectomywhich can simplify the complexity of surgery to a certain extenteffectively reduce the operation time and the time of blocking the first hepatic portal. It has clinical value for promotion.

    Analysis of the Efficacy of Thoracoscopic Small-Incision Surgery for the Treatment of Lung Cancer

    Yang Wenrong, Yang Lijie, Li Aimin, Song Zheng, Li Zhonghua, Yang Wanchun, Cha Jianyuan
    2023, 8(10):  43-46. 
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    ObjectiveTo analyze the effect of thoracoscopic small-incision surgery for the treatment of lung cancer. MethodsA total of 76 patients with lung cancer admitted to the First Affiliated Hospital of Dali University from March 2020 to March 2022 were studied. The patients were randomly divided into two groups by the principle of double-blind grouping. The control group was treated with traditional thoracotomywhile the observation group was treated with thoracoscopic small-incision surgery. The surgical indicatorscoagulation function indicatorscomplication raterecurrence rate and quality of life were compared between two groups. ResultsThe surgical time of the observation group was similar to that of the control groupwith no statistical significance P>0.05. Compared with the control groupthe observation group had less intraoperative blood lossshorter postoperative catheterization time and hospital staymore lymph node dissectionand longer postoperative analgesia timewith statistical significanceP<0.05. There was no significant difference in the coagulation function indicators 24 hours after surgery between two groupsP>0.05. The score of postoperative quality of life in observation group was significantly higher than that of the control groupwhile the incidence of complications and recurrence rate in the control group were significantly higher than those in the observation groupP<0.05. ConclusionThoracoscopic small-incision surgery is effective in the treatment of lung cancer. Compared with traditional thoracotomyit has similar surgical difficulty and durationbut causes less damage to patientspromotes faster recoveryand has a lower recurrence ratewhich is beneficial for improving the quality of life of patients and deserves promotion.

    The Influence of Different Tranexamic Acid Regimens on Patients with Severe Knee Osteoarthritis after Total Knee Arthroplasty

    Song Xunzhou, Wang Hongping, Wang Mingyou, Lan Yuping
    2023, 8(10):  47-51. 
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    ObjectiveTo investigate the influence of different tranexamic acid regimens on patients with severe knee osteoarthritis after total knee arthroplastyTKA. MethodsA retrospective analysis was conducted on the medical records of patients who underwent unilateral TKA for the first time at the Department of OrthopedicsPanzhihua Central Hospitalfrom January 2019 to November 2021. According to different postoperative tranexamic acid regimensthe patients were divided into a control group intravenous infusion of 1 g tranexamic acid at 3 and 6 hours after surgeryand an experimental group intravenous infusion of 1 g tranexamic acid at 36 hours1and 2 days after surgery. The postoperative laboratory indicatorstotal perioperative blood loss and blood transfusionoccurrence of deep venous thrombosis of lower limbspostoperative painknee joint swellingand knee joint function were compared between the two groups. ResultsThe total perioperative blood lossperioperative blood transfusion rateresting pain score and knee swelling degree of the experimental group were significantly lower than those of the control groupwhile the knee function score of the experiment group was significantly higher than that of the control groupwith statistical significance P<0.05. ConclusionProlonged use of tranexamic acid after TKA can further reduce blood lossalleviate inflammatory responsereduce pain and swelling in the surgical areaand promote rapid recovery in patientswhich is worthy of clinical promotion.

    Study on the Mechanism of JAK2-STAT3 Signaling Pathway Mediated by Th1/Th2 Immune Balance Shift in the Occurrence of Infectious Preterm Birth

    Du Lingying, Li Zhonglian, Yang Qiongyan, Si Yanting, Guo Ying
    2023, 8(10):  52-58. 
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    ObjectiveTo investigate the Th1/Th2 immune imbalance and the involvement of the JAK2-STAT3 signaling pathway in the mechanism of infectious preterm birth. MethodsA total of 60 preterm patients treated at the First Affiliated Hospital of Dali University were selected as the research objectspreterm group. Based on the results of postpartum fetal membrane tissue pathological examinationthe preterm group was divided into the infectious preterm birth group and non-infectious preterm birth group. 20 puerperae who had full-term deliveries during the same period were selected as the control group. The expression levels of interferon-γ (IFN-γ), interleukin-4 IL-4), interleukin-6 IL-6and tumor necrosis factor-α (TNF-α) in the peripheral blood of the puerperae in the three groups were detected by ELISA kitsand the Th1/Th2 immune regulatory balance index was calculated. The expressions of STAT3 and nuclear factor-κBNF-κBproteins in fetal membrane tissue were detected by immunohistochemistry. ResultsThe expression levels of IFN-γ and TNF-α were significantly elevated in the preterm groupP<0.05), especially in the infectious preterm birth groupindicating that the Th1/Th2 immune balance had a significant shift toward Th1. The expression levels of IL-6STAT3and NF-κB proteins were significantly higher in the infectious preterm birth groupP<0.05), while there was no significant difference between the non-infectious preterm birth group and the control groupP>0.05. ConclusionThe Th1/Th2 immune balance may be involved in the occurrence of infectious preterm birth through TNF-α, NF-κBIL-6 and JAK2-STAT3 signaling pathways.

    Study on the Status Quo and Influencing Factors of Women's Knowledge-Attitude-Practice of Pelvic Inflammatory Disease in Panxi egion

    Li Chao, Luo Zongbao, Liu Qin, Wang Mingyou, Yang Yi
    2023, 8(10):  59-63. 
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    ObjectiveTo investigate and analyze the status quo and influencing factors of women's knowledge-attitude-practice of pelvic inflammatory diseasePIDin Panxi area. MethodsA questionnaire survey was conducted on a sample of urban and rural women in the Panxi region using a systematic stratified random sampling method. ResultsA total of 1 736 valid questionnaires were collected. The results of the univariate analysis showed that ageeducation leveloccupationmarital statusand ethnicity were influencing factors for the knowledge-attitude-practice of women in the Panxi region regarding PIDP<0.05. Logistic regression analysis results showed that educational level and willingness to learn PID knowledge were the main factors affecting cognition. Cognitionwillingness to learn PID knowledge and marital status were the main factors affecting attitudes. Cognitionattitudeageeducation levelmarital statusoccupation were the main factors influencing practices. Internet promotiondoctor's promotionradio and televisionand posters were the preferred methods of promotion among local women. ConclusionThe knowledge and attitudes of women in the Panxi region regarding PID need to be strengthened. Conducting various forms of promotion on PID prevention and treatment can improve the awareness of PID prevention and treatment among women in the Panxi region and promote the formation of behaviors related to PID prevention and treatment. 

    The Clinical Value of Bedside Pulmonary Ultrasound in the Diagnosis and Treatment of Critical Neonatal Pneumothorax

    Bao Lingyun, Yin Lijuan
    2023, 8(10):  64-67. 
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    ObjectiveTo explore the diagnostic value of bedside pulmonary ultrasound in neonatal pneumothorax and its suitability for promotion in primary hospitals. MethodsA prospective study was conducted on critically ill newborns with suspected of pneumothorax admitted to the neonatal intensive care unit of Kunming Children's Hospital from January 2021 to October 2022. The enrolled patients received both bedside ultrasonography and X-ray examination. Based on clinical manifestationsthe accuracy and duration of the two methods were compared. ResultsA total of 66 pneumothorax cases were confirmed among the 76 casesof which 66 cases were confirmed by pulmonary ultrasound and 55 cases were confirmed by X-ray. According to the analysis of McNemar's and Kappa teststhe difference in diagnostic accuracy between the two methods was statistically significantP<0.001), and the diagnostic results were moderately consistent Kappa=0.656. The duration of pulmonary ultrasound examination was 5.63 minutes shorter than that of X-ray examinationand the difference was statistically significantP<0.001. ConclusionBedside pulmonary ultrasound is easy to learnand is an efficient and convenient method for the diagnosis and treatment of neonatal pneumothorax. It is superior to X-ray imaging and is suitable for promotion in primary hospitals.

    Analysis of Clinical Significance of Cytokine and Acute Protein Detection in Patients with Mycobacterium Infectious Lung Disease

    Li Xiangfang, Wang Xuan, Ding Shoupeng, Ma Fengqian, Wu Lixian
    2023, 8(10):  68-71. 
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    ObjectiveTo study the clinical significance of serum cytokine and acute protein detection in patients with mycobacterium infectious lung disease. MethodsThe levels of interleukin(IL)-1interleukin-2 receptorIL-2R), IL-6IL-8IL-10tumor necrosis factor-α(TNF-α), α2-macroglobulinAMG), complement C1q and B factors in serum of the target population were detected by enzyme-linked immunosorbent assay and immunonephelometry. ResultsCompared with healthy subjects control group), the levels of IL-2R and TNF-α in the serum of pulmonary tuberculosis patients MTB groupand non-tuberculous mycobacterium lung disease patients NTM groupwere significantly increasedwhile the levels of AMG was significantly decreasedand the levels of C1q and B factors were significantly increasedwith statistical significance P<0.05. Howeverthere was no significant difference in the levels of cytokine and acute protein between the MTB group and the NTM groupP>0.05. ConclusionThe levels of TNF-α were significantly increased in the serum of patients in both the MTB and NTM groupswhich can be used to understand the pathogenesis of these two lung diseases. The increased levels of IL-2R were associated with disease activity. The decreased levels of AMG can serve as a biomarker for immune system dysregulation. 

    Analysis of the Diagnostic Value of Combined Detection of MIP-1β、IL-27 and IL-35 in Tuberculous Pleural Effusion

    Zhong Xiaoxia, Zhou Shixiong, Zhang Le, Cai Weiling
    2023, 8(10):  72-75. 
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    ObjectiveTo explore the diagnostic value of combined detection of macrophage inflammatory protein 1β(MIP-1β)、 interleukinIL-27 and IL-35 in tuberculous pleural effusionTPE. MethodsA total of 106 patients with TPE admitted to Luojiang District People's Hospital and Medical Group Hospital in Deyang City from May 2021 to December 2022 were selected as the study subjectsresearch group), and 106 patients with malignant pleural effusion MPEadmitted at the same time were selected as the control group. The expression levels of MIP-1β, IL-27 and IL-35 in the serum of the two groups were detected by enzyme-linked immunosorbent assay. The expression levels of the three cytokines were compared before and after treatment in the research groupand receiver operating characteristicROCcurve was plotted to evaluate the diagnostic value of individual and combined detection of the markers. ResultsCompared to the control groupthe levels of serum MIP-1β and IL-35 in the research group were significantly increasedwhile the level of IL-27 was significantly decreasedwith statistical significanceP<0.01. Compared to before treatmentthe levels of serum MIP-1β, IL-27 and IL-35 in the research group were significantly decreased after treatmentwith statistical significanceP<0.01. ROC curve analysis showed that the diagnostic efficacy of the combined detection of MIP-1β, IL-27 and IL-35 was significantly higher than that of individual markersP<0.05. ConclusionMIP-1β, IL-27 and IL-35 can be used for the differential diagnosis of TPE and MPEand the combined detection can improve the diagnostic efficiency.

    The Prognostic Value of NLR and PLR in Patients with Maintenance Hemodialysis

    Li Chunyan
    2023, 8(10):  76-80. 
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    ObjectiveTo explore the prognostic value of neutrophil-lymphocyte ratioNLRand platelet-lymphocyte ratio PLRin patients with maintenance hemodialysisMHD. MethodsMedical records of 119 patients who underwent MHD treatment at Baoshan People's Hospital from January 2017 to October 2020 were collectedand the patients were grouped according to the median PLR and NLRand the clinical data of each group were evaluated. Kaplan-Meier survival curve was used to analyze all-cause mortality rates in the NLR and PLR groups. COX regression models were used to analyze the risk factors for all-cause mortality in the patients. The predictive value of NLR for all-cause mortality in MHD patients was evaluated using receiver operator characteristicROCcurve. ResultsIn the PLR groupthere were no significant differences in laboratory parameters and all-cause mortality rates between the two groupsP>0.05. In the NLR group,  there were significant differences in albuminhypersensitive C-reactive protein hsCRP), single-pool urea clearance rateand all-cause mortality rates between the two groups P<0.05. The adjusted COX regression model showed that the increasing ageelevated NLRhsCRP and decreased single-pool urea clearance rate were independent predictors of all-cause mortality rate. The ROC curve analysis showed that the area under the curve for NLR in predicting all-cause mortality in MHD patients was 0.71695%CI0.598-0.833), with a sensitivity of 78.30% and specificity of 64.60%. ConclusionNLR can independently predict the prognosis of MHD patients.

    The Predictive Value of Stone CT Value for the Efficiency of Flexible Ureteroscopic Lithotomy

    Xia Wangxu, He Yongfang, Chen Xiaobo, Huang Chuanfen
    2023, 8(10):  81-84. 
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    ObjectiveTo analyze the predictive value of stone CT value for the efficiency of flexible ureteroscopic lithotomy. MethodsA retrospective analysis was conducted on the medical records of 135 patients who underwent flexible ureteroscopic lithotomy at Changshou District People's Hospital in Chongqing. The patients' general preoperative information and stone datanumbervolumeand CT valuewere recorded. After 3 months of postoperative follow-upthe patients were divided into stone clearance group and stone residue group based on the stone clearance status. Univariate analysismultivariate Logistic regression analysisand receiver operator characteristicROCcurve analysis were performed. ResultsThe univariate analysis showed that there were statistically significant differences in stone numberstone volumeand stone CT value between the two groupsP<0.05. The results of multivariate Logistic regression analysis showed that the stone number 2 and elevated stone CT value were risk factors for residual stones after flexible ureteroscopic lithotomyP<0.05. The ROC curve analysis results showed that the predicted cut-off value of stone CT for residual stones after flexible ureteroscopic lithotomy was 1 092.75 HUwith an area under the curve of 0.72595%CI0.632-0.791), sensitivity of 51.91%and specificity of 84.72%. ConclusionThe residual stones after flexible ureteroscopic lithotripsy are mainly influenced by stone number and stone CT value. Stone CT value has a high diagnostic efficacy in predicting residual stones after flexible ureteroscopic lithotripsy. 

    Correlation Analysis of Hyperthyroidism and Bone Mineral Density in Postmenopausal Women

    Li Ye, Yu Yanfang, Chen Bin, Su Heng
    2023, 8(10):  85-89. 
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    ObjectiveTo explore the correlation between hyperthyroidism and bone mineral densityBMDin postmenopausal women. MethodsA total of 220 postmenopausal women who visited the First People's Hospital of Yunnan Province from October 2021 to April 2022 were selected as the study subjects. BMD and thyroid function indicators were compared among all participants. The patients with hyperthyroidism were divided into different subgroups according to the duration of the diseaseand BMD measurements were compared among the subgroups. ResultsThe BMD values of lumbar vertebraneck of femurWards trianglegreater trochanter and the whole body in patients with hyperthyroidism were significantly lower than in those without hyperthyroidism. Among patients with hyperthyroidismthose with a disease duration of 1 year had significantly lower BMD values in the lumbar spine compared to those with a disease duration of <1 yearP<0.05. The levels of free triiodothyronineFT3were negatively correlated with BMD values in the neck of femurWards triangleand the whole bodywhile the levels of free thyroxineFT4were negatively correlated with BMD values in Wards triangle. ConclusionThe BMD values of postmenopausal women with hyperthy-roidism are significantly lower than those without hyperthyroidism. Prolonged disease duration is more likely to lead to a decrease in lumbar spine BMD. FT3 and FT4 levels are negatively correlated with BMD values.

    Epidemiological Characteristics of Rabies in Yunnan Province from 2000 to 2020

    Zhang Yuzhen
    2023, 8(10):  90-94. 
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    ObjectiveTo analyze the epidemiological characteristics of rabies in Yunnan Province from 2000 to 2020. MethodsThe rabies epidemic data of Yunnan Province were collected. Based on the historical epidemic dataYunnan rovince was divided into the eastern epidemic areasEEAand the western epidemic areasWEA. According to the Tropic of CancerYunnan rovince was divided into the northern epidemic areas NEAand the southern epidemic areas SEA. Descriptive epidemiological methods were used to compare and analyze the epidemiological distribution characteristics of each epidemic area and prefecture during the wave of rabies epidemic from 2000 to 2020. ResultsFrom 2000 to 2020a total of 996 human rabies cases were reported in Yunnan Provinceaffecting 80.62% 104/129counties districtsin all 16 prefectures. The number of cases was generally higher in EEA and lower in WEAwhile EEA and WEA showed the distribution characteristics of higher in the south and lower in the northrespectively. The ratio of cases in EEA and WEA was 3.791and that in SEA and NEA was 1.341. The average annual incidence in EEA0.14/100 000was higher than that in WEA0.06/100 000), and the average annual incidence in SEA 0.17/100 000was higher than that in NEA0.07/100 000. The prefectures with higher average annual incidences were concentrated in SEAnamely Xishuangbanna Dai Autonomous Prefecture0.28/100 000), Wenshan Zhuang and Miao Autonomous Prefecture 0.28/100 000and Honghe Hani and Yi Autonomous Prefecture0.22/100 000. ConclusionThe border area where ChinaLaos and Vietnam meet should be considered as the key areas for rabies surveillancepreventionand research in Yunnan Province. 

    Investigation and Analysis on the Perceptions of Attitudes of Respiratory System Critically Ill Patients and Their Family Members towards Death

    Hu Yongli, Dai Rufen, Yang Yanxia, Tan Zhengqiao
    2023, 8(10):  95-100. 
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    ObjectiveTo investigate the perceptions of attitudes of respiratory system critically ill patients and their family members towards deathand provide reference for death education in this population. MethodsA total of 226 respiratory system critically ill patients and their family members from the People's Hospital of Dali Bai Autonomous Prefecture from May to October 2022 were randomly selected as investigation objects. Questionnaires and the Death Attitude Mapping Scale were used for investigation and analysis. ResultsThe death attitude of 226 respiratory system critically ill patients and their family members characterized by acceptance of death as a natural processbut also accompanied by psychological tendencies of avoidance and fear of death. There were significant differences in attitudes towards death among respiratory system critically ill patients and their family members with different characteristics. ConclusionDeath education should be conducted in different ways for respiratory system critically ill patients and their family members with different characteristicsaiming to establish a correct understanding of death and promote the value of cherishing and treasuring life.