Table of Content

15 October 2023, Volume 8 Issue 10

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Anti-Tumor Effect and Mechanism of CⅡ-3 Extractive from Periplaneta americana on S180 Sarcoma-Bearing Mice

Lu Li, He Xu, Zhang Yanju, Peng Fang

2023, 8(10):  1-8. 

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Objective：To investigate the anti-tumor effect and mechanism of CⅡ-3 extractive from Periplaneta americana on S180 sarcoma-bearing mice. Methods： S180 sarcoma-bearing mice were randomly divided into model group， positive control （CTX） group， high-dose， medium-dose and low-dose CⅡ-3 groups， and a normal control group， with 10 mice in each group. The pathological changes of tumor tissue in each group were observed after administration， and the tumor inhibition rate was calculated. ELISA kits were used to test the levels of vascular endothelial growth factor（VEGF） and telomerase（TE） in serum. The expression of p53， B-cell lymphoma 2（Bcl-2）， cysteinyl asparate specific protease-3（Caspase-3）， microvessel density （MVD） and cyclooxygenase-2（COX-2） protein in tumor tissue were detected by immunohistochemistry. Results： The tumor inhibition rates of CTX group， high-dose， medium-dose， and low-dose CⅡ-3 groups were 85.71%， 55.71%， 44.28%， 34.28%， respectively. The necrotic area of tumor tissue was obvious in high-dose and medium-dose CⅡ-3 groups. Compared with the model group， the TE activity was decreased in high-dose CⅡ-3 group（P<0.05）， and the expression of p53， Bcl-2， MVD and COX-2 in tumor tissues of high-dose and medium-dose CⅡ-3 groups were significantly decreased（P<0.01）， while the Caspase-3 expression was significantly increased（P<0.01）. Conclusion： CⅡ-3 can significantly inhibit the growth of S180 sarcoma， and its mechanism may be related to the reduction of TE activity， the decrease of p53， Bcl-2， MVD， COX-2 expression， and the increase of Caspase-3 expression in tumor tissue.

Research on the Survey of Medicinal Plant Resources in Binchuan County Based on the Fourth National Survey of Chinese Materia Medica Resources

Huang Bo, Zhang Huayan, Yang Xiujuan, Zhang Ping, He Yunchang,

2023, 8(10):  9-15. 

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Objective： Based on the Fourth National Survey of Chinese Materia Medica Resources， the species， distribution and cultivation of wild traditional Chinese medicine resources in Binchuan County were investigated. Methods： The medicinal plants in Binchuan County were statistically analyzed through field sample survey， interview survey， collection of plant specimens and reference to relevant literature. Results： There were 583 species of medicinal plants belonging to 388 genera in 101 families in this county. Among them， the dominant family of medicinal resources was Asteraceae， followed by Leguminosae. There were relatively few key medicinal plants with large reserves. There were 22 kinds of medicinal plant which were mainly cultivated in this county. Conclusion： Binchuan County is rich in wild medicinal plant resources， so it is necessary to strengthen the protection of medicinal plant resources in this region and ensure their sustainable utilization during development and utilization.

The Impact of Pharmaceutical Care Intervention on Medication Compliance and Efficacy in Hypertension Patients of Bai Ethnic Minority

Li Xia , Dong Xiaowei, Qiu Lin, Yang Pihui, Dong Ying, Wang Qinggui, Gu Yun

2023, 8(10):  16-20. 

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Objective： To investigate the impact of pharmaceutical care intervention on medication compliance and efficacy in hypertension patients of Bai ethnic minority. Methods： A total of 106 essential hypertension patients of Bai ethnic minority who were treated in the First Affiliated Hospital of Dali University from January to June 2020 were selected as study objects， and randomly divided into control group and intervention group. The control group received routine pharmaceutical care， and the intervention group adopted the plan-do-check-action（PDCA） cycle to carry out pharmaceutical care. The quality of life scores， blood pressure control， medication compliance and incidence of adverse reactions were compared before and after intervention in both groups. Results： After intervention， the scores of each dimension in the quality of life scale in the intervention group were significantly higher than those in the control group， and the systolic and diastolic blood pressure were significantly lower than those in the control group， with statistical significance（P<0.01）； the medication compliance rate in the intervention group was significantly higher than that in the control group， and the incidence of adverse drug reactions was significantly lower than that in the control group， with statistical significance（P<0.01）. Conclusion： Adopting PDCA cycle to carry out pharmaceutical care can improve medication compliance of hypertension patients of Bai ethnic minority and help them better control blood pressure.

The Inhibitory Activity of Pinus yunnanensis Pine Extract with Anti-HIV Activity against Human Coronavirus 229E

Li Yafei, Shang Fangjian, Luo Chunyu, Shi Zhefang, Liu Qi,

2023, 8(10):  21-26. 

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Objective： To evaluate the inhibitory activity of Pinus yunnanensis pine extract（referred to as "pine extract"） with anti-HIV activity against human coronavirus HCoV-229E and preliminarily determine its target. Methods： A cell-cell fusion model and  model mediated by HCoV-229E S protein were constructed to detect the inhibitory activity of pine extract against HCoV-229E. Time-of-addition and time-of-removal experiments were performed to determine the target and the timing of action. Results： Pine extract could inhibit the cell-cell fusion mediated by HCoV-229E S protein， with an IC50 of （0.136±0.010） mg/mL. It effectively inhibited HCoV-229E infection， with an IC50 of （0.069±0.015） mg/mL. Time-of-removal and time-of-addition experiments showed that pine extract targeted the HCoV-229E S protein and acted in the early stage of infection（1 h before）； different concentrations of pine tower extracts have no significant toxicity to 293T and Huh-7 cells. Conclusion： Pine extract can target the HCoV-229E S protein and inhibit HCoV-229E infection in the early stage， making it a safe candidate drug.

Research on the Application of Gold Nanorods in the Detection of Circulating Antigens in Clonorchis sinensis Serum

Chen Liping, Lian Xiaoli, Cai Zihan, Li Qian, Ouyang Tianzhao, Yang Yimei

2023, 8(10):  27-33. 

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Objective： To study the detection effect of gold nanorods on early and low worm burden of Clonorchis sinensis. Methods： Gold nanorods were labeled with different concentrations of thiolated Clonorchis sinensis-specific IgG antibodies. The absorption peaks of the gold nanorods were scanned using a UV spectrophotometer to observe the magnitude of the peak shift and determine the optimal labeling concentration. The gold nanorods labeled with the optimal concentration of antibodies were used to detect circulating antigens in rat serum with different infection degrees， infection times， and dilutions.  Results： The maximum peak shift was 20.0 nm when the gold nanorods were labeled with 20 μg/mL antibodies. The gold nanorods labeled with Clonorchis sinensis specific IgG antibodies could detect circulating antigens in rat serum at 3， 10 ，17 and 31 d after infection with 50， 100 and 200 cercariae， as well as at a dilution of 1∶400. Conclusion： Gold nanorods labeled with Clonorchis sinensis specific IgG antibodies have significant advantages in the detection of early and low worm burden of Clonorchis sinensis.

Efficacy Analysis of Ｇastroscopic Metal Titanium Clip Combined with Medical Adhesive in the Treatment of Gastric Fundal Varices

Ma Mengxia, Tao Zhongyuan, Guo Shunhong, Zhao Chunping, Li Bowen, Zhang Qinyuan

2023, 8(10):  34-37. 

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Objective： To investigate the clinical efficacy of gastroscopic metal titanium clip combined with medical adhesive in the treatment of gastric fundal varices. Methods： A retrospective analysis was performed on the medical records of 80 patients who underwent gastroscopic treatment for gastric fundal varices with medical adhesive at the Endoscopy Center of the First People's Hospital of Dali City from June 1， 2020 to June 30， 2021. The clinical efficacy and safety of the monotherapy（monotherapy group） and metal titanium clip combined therapy（combined group） were compared. Results： Compared with the monotherapy group， the combined group had a significantly increased amount of medical adhesive used， with a statistically significant difference（P<0.05）. However， the rebleeding rate between the two groups was only statistically significant at 3 months after surgery（P<0.05）， while there was no statistically significant difference at other time points（P>0.05）. Additionally， no cases of ectopic embolism occurred during the 12-month follow-up period in both groups. Conclusion： Gastroscopic metal titanium clip combined with medical adhesive in the treatment of gastric fundal varices can reduce the rate of rebleeding and is a safe and effective treatment method.

Selection of Approach for Laparoscopic Anatomic Left Hepatectomy

Li Xiaoju, , Wang Xingru, , Xiong Liqiao, Wan Dandan, Liu Tianxi,

2023, 8(10):  38-42. 

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Objective： To investigate the safety and feasibility of hepatic parenchymal approach in laparoscopic anatomic left hepatectomy. Methods： A retrospective analysis was conducted on the clinical data of 151 patients who underwent laparoscopic left hepatectomy for benign diseases at the Department of Hepatobiliary Surgery， the Second People's Hospital of Qujing City from August 2018 to August 2021. According to the different surgical approaches， the patients were divided into a modified group and a traditional group. The modified group used a liver parenchyma priority approach for liver resection， while the traditional group used a pedicle-first approach. The preoperative conditions， surgical resection scope， intraoperative conditions， and postoperative outcomes were compared between the two groups. Results： There were no statistically significant differences（P>0.05） in preoperative and postoperative indicators，surgical resection scope， and intraoperative blood loss between the two groups. The modified group had significantly shorter operation time and first porta hepatis clamping time compared to the traditional group， with statistical significance （P<0.05）. Conclusion： Hepatic parenchyma priority approach is safe and feasible in laparoscopic left hepatectomy， which can simplify the complexity of surgery to a certain extent， effectively reduce the operation time and the time of blocking the first hepatic portal. It has clinical value for promotion.

Analysis of the Efficacy of Thoracoscopic Small-Incision Surgery for the Treatment of Lung Cancer

Yang Wenrong, Yang Lijie, Li Aimin, Song Zheng, Li Zhonghua, Yang Wanchun, Cha Jianyuan

2023, 8(10):  43-46. 

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Objective： To analyze the effect of thoracoscopic small-incision surgery for the treatment of lung cancer. Methods： A total of 76 patients with lung cancer admitted to the First Affiliated Hospital of Dali University from March 2020 to March 2022 were studied. The patients were randomly divided into two groups by the principle of double-blind grouping. The control group was treated with traditional thoracotomy， while the observation group was treated with thoracoscopic small-incision surgery. The surgical indicators， coagulation function indicators， complication rate， recurrence rate and quality of life were compared between two groups. Results： The surgical time of the observation group was similar to that of the control group， with no statistical significance （P>0.05）. Compared with the control group， the observation group had less intraoperative blood loss， shorter postoperative catheterization time and hospital stay， more lymph node dissection， and longer postoperative analgesia time， with statistical significance（P<0.05）. There was no significant difference in the coagulation function indicators 24 hours after surgery between two groups（P>0.05）. The score of postoperative quality of life in observation group was significantly higher than that of the control group， while the incidence of complications and recurrence rate in the control group were significantly higher than those in the observation group（P<0.05）. Conclusion： Thoracoscopic small-incision surgery is effective in the treatment of lung cancer. Compared with traditional thoracotomy， it has similar surgical difficulty and duration， but causes less damage to patients， promotes faster recovery， and has a lower recurrence rate， which is beneficial for improving the quality of life of patients and deserves promotion.

The Influence of Different Tranexamic Acid Regimens on Patients with Severe Knee Osteoarthritis after Total Knee Arthroplasty

Song Xunzhou, Wang Hongping, Wang Mingyou, Lan Yuping

2023, 8(10):  47-51. 

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Objective： To investigate the influence of different tranexamic acid regimens on patients with severe knee osteoarthritis after total knee arthroplasty（TKA）. Methods： A retrospective analysis was conducted on the medical records of patients who underwent unilateral TKA for the first time at the Department of Orthopedics， Panzhihua Central Hospital， from January 2019 to November 2021. According to different postoperative tranexamic acid regimens， the patients were divided into a control group （intravenous infusion of 1 g tranexamic acid at 3 and 6 hours after surgery） and an experimental group （intravenous infusion of 1 g tranexamic acid at 3， 6 hours， 1， and 2 days after surgery）. The postoperative laboratory indicators， total perioperative blood loss and blood transfusion， occurrence of deep venous thrombosis of lower limbs， postoperative pain， knee joint swelling， and knee joint function were compared between the two groups. Results： The total perioperative blood loss， perioperative blood transfusion rate， resting pain score and knee swelling degree of the experimental group were significantly lower than those of the control group， while the knee function score of the experiment group was significantly higher than that of the control group， with statistical significance （P<0.05）. Conclusion： Prolonged use of tranexamic acid after TKA can further reduce blood loss， alleviate inflammatory response， reduce pain and swelling in the surgical area， and promote rapid recovery in patients， which is worthy of clinical promotion.

Study on the Mechanism of JAK2-STAT3 Signaling Pathway Mediated by Th1/Th2 Immune Balance Shift in the Occurrence of Infectious Preterm Birth

Du Lingying, Li Zhonglian, Yang Qiongyan, Si Yanting, Guo Ying

2023, 8(10):  52-58. 

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Objective： To investigate the Th1/Th2 immune imbalance and the involvement of the JAK2-STAT3 signaling pathway in the mechanism of infectious preterm birth. Methods： A total of 60 preterm patients treated at the First Affiliated Hospital of Dali University were selected as the research objects（preterm group）. Based on the results of postpartum fetal membrane tissue pathological examination， the preterm group was divided into the infectious preterm birth group and non-infectious preterm birth group. 20 puerperae who had full-term deliveries during the same period were selected as the control group. The expression levels of interferon-γ （IFN-γ）， interleukin-4 （IL-4）， interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） in the peripheral blood of the puerperae in the three groups were detected by ELISA kits， and the Th1/Th2 immune regulatory balance index was calculated. The expressions of STAT3 and nuclear factor-κB（NF-κB） proteins in fetal membrane tissue were detected by immunohistochemistry. Results： The expression levels of IFN-γ and TNF-α were significantly elevated in the preterm group（P<0.05）， especially in the infectious preterm birth group， indicating that the Th1/Th2 immune balance had a significant shift toward Th1. The expression levels of IL-6， STAT3， and NF-κB proteins were significantly higher in the infectious preterm birth group（P<0.05）， while there was no significant difference between the non-infectious preterm birth group and the control group（P>0.05）. Conclusion： The Th1/Th2 immune balance may be involved in the occurrence of infectious preterm birth through TNF-α， NF-κB， IL-6 and JAK2-STAT3 signaling pathways.

Study on the Status Quo and Influencing Factors of Women's Knowledge-Attitude-Practice of Pelvic Inflammatory Disease in Panxi Ｒegion

Li Chao, Luo Zongbao, Liu Qin, Wang Mingyou, Yang Yi

2023, 8(10):  59-63. 

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Objective： To investigate and analyze the status quo and influencing factors of women's knowledge-attitude-practice of pelvic inflammatory disease（PID） in Panxi area. Methods： A questionnaire survey was conducted on a sample of urban and rural women in the Panxi region using a systematic stratified random sampling method. Results： A total of 1 736 valid questionnaires were collected. The results of the univariate analysis showed that age， education level， occupation， marital status， and ethnicity were influencing factors for the knowledge-attitude-practice of women in the Panxi region regarding PID（P<0.05）. Logistic regression analysis results showed that educational level and willingness to learn PID knowledge were the main factors affecting cognition. Cognition， willingness to learn PID knowledge and marital status were the main factors affecting attitudes. Cognition， attitude， age， education level， marital status， occupation were the main factors influencing practices. Internet promotion， doctor's promotion， radio and television， and posters were the preferred methods of promotion among local women. Conclusion： The knowledge and attitudes of women in the Panxi region regarding PID need to be strengthened. Conducting various forms of promotion on PID prevention and treatment can improve the awareness of PID prevention and treatment among women in the Panxi region and promote the formation of behaviors related to PID prevention and treatment. 

The Clinical Value of Bedside Pulmonary Ultrasound in the Diagnosis and Treatment of Critical Neonatal Pneumothorax

Bao Lingyun, Yin Lijuan

2023, 8(10):  64-67. 

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Objective： To explore the diagnostic value of bedside pulmonary ultrasound in neonatal pneumothorax and its suitability for promotion in primary hospitals. Methods： A prospective study was conducted on critically ill newborns with suspected of pneumothorax admitted to the neonatal intensive care unit of Kunming Children's Hospital from January 2021 to October 2022. The enrolled patients received both bedside ultrasonography and X-ray examination. Based on clinical manifestations， the accuracy and duration of the two methods were compared. Results： A total of 66 pneumothorax cases were confirmed among the 76 cases， of which 66 cases were confirmed by pulmonary ultrasound and 55 cases were confirmed by X-ray. According to the analysis of McNemar's and Kappa tests， the difference in diagnostic accuracy between the two methods was statistically significant（P<0.001）， and the diagnostic results were moderately consistent （Kappa=0.656）. The duration of pulmonary ultrasound examination was 5.63 minutes shorter than that of X-ray examination， and the difference was statistically significant（P<0.001）. Conclusion： Bedside pulmonary ultrasound is easy to learn， and is an efficient and convenient method for the diagnosis and treatment of neonatal pneumothorax. It is superior to X-ray imaging and is suitable for promotion in primary hospitals.

Analysis of Clinical Significance of Cytokine and Acute Protein Detection in Patients with Mycobacterium Infectious Lung Disease

Li Xiangfang, Wang Xuan, Ding Shoupeng, Ma Fengqian, Wu Lixian

2023, 8(10):  68-71. 

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Objective： To study the clinical significance of serum cytokine and acute protein detection in patients with mycobacterium infectious lung disease. Methods： The levels of interleukin（ＩＬ）-1， interleukin-2 receptor（IL-2R）， IL-6， IL-8， IL-10， tumor necrosis factor-α（TNF-α）， α2-macroglobulin（AMG）， complement C1q and B factors in serum of the target population were detected by enzyme-linked immunosorbent assay and immunonephelometry. Results： Compared with healthy subjects （control group）， the levels of IL-2R and TNF-α in the serum of pulmonary tuberculosis patients （MTB group） and non-tuberculous mycobacterium lung disease patients （NTM group） were significantly increased， while the levels of AMG was significantly decreased， and the levels of C1q and B factors were significantly increased， with statistical significance （P<0.05）. However， there was no significant difference in the levels of cytokine and acute protein between the MTB group and the NTM group（P>0.05）. Conclusion： The levels of TNF-α were significantly increased in the serum of patients in both the MTB and NTM groups， which can be used to understand the pathogenesis of these two lung diseases. The increased levels of IL-2R were associated with disease activity. The decreased levels of AMG can serve as a biomarker for immune system dysregulation. 

Analysis of the Diagnostic Value of Combined Detection of MIP-1β、IL-27 and IL-35 in Tuberculous Pleural Effusion

Zhong Xiaoxia, Zhou Shixiong, Zhang Le, Cai Weiling

2023, 8(10):  72-75. 

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Objective： To explore the diagnostic value of combined detection of macrophage inflammatory protein 1β（MIP-1β）、 interleukin（IL） -27 and IL-35 in tuberculous pleural effusion（TPE）. Methods： A total of 106 patients with TPE admitted to Luojiang District People's Hospital and Medical Group Hospital in Deyang City from May 2021 to December 2022 were selected as the study subjects（research group）， and 106 patients with malignant pleural effusion （MPE） admitted at the same time were selected as the control group. The expression levels of MIP-1β， IL-27 and IL-35 in the serum of the two groups were detected by enzyme-linked immunosorbent assay. The expression levels of the three cytokines were compared before and after treatment in the research group， and receiver operating characteristic（ROC） curve was plotted to evaluate the diagnostic value of individual and combined detection of the markers. Results： Compared to the control group， the levels of serum MIP-1β and IL-35 in the research group were significantly increased， while the level of IL-27 was significantly decreased， with statistical significance（P<0.01）. Compared to before treatment， the levels of serum MIP-1β， IL-27 and IL-35 in the research group were significantly decreased after treatment， with statistical significance（P<0.01）. ROC curve analysis showed that the diagnostic efficacy of the combined detection of MIP-1β， IL-27 and IL-35 was significantly higher than that of individual markers（P<0.05）. Conclusion： MIP-1β， IL-27 and IL-35 can be used for the differential diagnosis of TPE and MPE， and the combined detection can improve the diagnostic efficiency.

The Prognostic Value of NLR and PLR in Patients with Maintenance Hemodialysis

Li Chunyan

2023, 8(10):  76-80. 

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Objective： To explore the prognostic value of neutrophil-lymphocyte ratio（NLR） and platelet-lymphocyte ratio （PLR） in patients with maintenance hemodialysis（MHD）. Methods： Medical records of 119 patients who underwent MHD treatment at Baoshan People's Hospital from January 2017 to October 2020 were collected， and the patients were grouped according to the median PLR and NLR， and the clinical data of each group were evaluated. Kaplan-Meier survival curve was used to analyze all-cause mortality rates in the NLR and PLR groups. COX regression models were used to analyze the risk factors for all-cause mortality in the patients. The predictive value of NLR for all-cause mortality in MHD patients was evaluated using receiver operator characteristic（ROC） curve. Results： In the PLR group， there were no significant differences in laboratory parameters and all-cause mortality rates between the two groups（P>0.05）. In the NLR group，  there were significant differences in albumin， hypersensitive C-reactive protein （hsCRP）， single-pool urea clearance rate， and all-cause mortality rates between the two groups （P<0.05）. The adjusted COX regression model showed that the increasing age， elevated NLR， hsCRP and decreased single-pool urea clearance rate were independent predictors of all-cause mortality rate. The ROC curve analysis showed that the area under the curve for NLR in predicting all-cause mortality in MHD patients was 0.716（95%CI： 0.598-0.833）， with a sensitivity of 78.30% and specificity of 64.60%. Conclusion： NLR can independently predict the prognosis of MHD patients.

The Predictive Value of Stone CT Value for the Efficiency of Flexible Ureteroscopic Lithotomy

Xia Wangxu, He Yongfang, Chen Xiaobo, Huang Chuanfen

2023, 8(10):  81-84. 

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Objective： To analyze the predictive value of stone CT value for the efficiency of flexible ureteroscopic lithotomy. Methods： A retrospective analysis was conducted on the medical records of 135 patients who underwent flexible ureteroscopic lithotomy at Changshou District People's Hospital in Chongqing. The patients' general preoperative information and stone data（number， volume， and CT value） were recorded. After 3 months of postoperative follow-up， the patients were divided into stone clearance group and stone residue group based on the stone clearance status. Univariate analysis， multivariate Logistic regression analysis， and receiver operator characteristic（ROC） curve analysis were performed. Results： The univariate analysis showed that there were statistically significant differences in stone number， stone volume， and stone CT value between the two groups（P<0.05）. The results of multivariate Logistic regression analysis showed that the stone number ≥2 and elevated stone CT value were risk factors for residual stones after flexible ureteroscopic lithotomy（P<0.05）. The ROC curve analysis results showed that the predicted cut-off value of stone CT for residual stones after flexible ureteroscopic lithotomy was 1 092.75 HU， with an area under the curve of 0.725（95%CI： 0.632-0.791）， sensitivity of 51.91%， and specificity of 84.72%. Conclusion： The residual stones after flexible ureteroscopic lithotripsy are mainly influenced by stone number and stone CT value. Stone CT value has a high diagnostic efficacy in predicting residual stones after flexible ureteroscopic lithotripsy. 

Correlation Analysis of Hyperthyroidism and Bone Mineral Density in Postmenopausal Women

Li Ye, Yu Yanfang, Chen Bin, Su Heng

2023, 8(10):  85-89. 

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Objective： To explore the correlation between hyperthyroidism and bone mineral density（BMD） in postmenopausal women. Methods： A total of 220 postmenopausal women who visited the First People's Hospital of Yunnan Province from October 2021 to April 2022 were selected as the study subjects. BMD and thyroid function indicators were compared among all participants. The patients with hyperthyroidism were divided into different subgroups according to the duration of the disease， and BMD measurements were compared among the subgroups. Results： The BMD values of lumbar vertebra， neck of femur， Wards triangle， greater trochanter and the whole body in patients with hyperthyroidism were significantly lower than in those without hyperthyroidism. Among patients with hyperthyroidism， those with a disease duration of ≥1 year had significantly lower BMD values in the lumbar spine compared to those with a disease duration of <1 year（P<0.05）. The levels of free triiodothyronine（FT3） were negatively correlated with BMD values in the neck of femur， Wards triangle， and the whole body， while the levels of free thyroxine（FT4） were negatively correlated with BMD values in Wards triangle. Conclusion： The BMD values of postmenopausal women with hyperthy-roidism are significantly lower than those without hyperthyroidism. Prolonged disease duration is more likely to lead to a decrease in lumbar spine BMD. FT3 and FT4 levels are negatively correlated with BMD values.

Epidemiological Characteristics of Rabies in Yunnan Province from 2000 to 2020

Zhang Yuzhen

2023, 8(10):  90-94. 

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Objective： To analyze the epidemiological characteristics of rabies in Yunnan Province from 2000 to 2020. Methods： The rabies epidemic data of Yunnan Province were collected. Based on the historical epidemic data， Yunnan Ｐrovince was divided into the eastern epidemic areas（EEA） and the western epidemic areas（WEA）. According to the Tropic of Cancer， Yunnan Ｐrovince was divided into the northern epidemic areas （NEA） and the southern epidemic areas （SEA）. Descriptive epidemiological methods were used to compare and analyze the epidemiological distribution characteristics of each epidemic area and prefecture during the wave of rabies epidemic from 2000 to 2020. Results： From 2000 to 2020， a total of 996 human rabies cases were reported in Yunnan Province， affecting 80.62% （104/129） counties （districts） in all 16 prefectures. The number of cases was generally higher in EEA and lower in WEA， while EEA and WEA showed the distribution characteristics of higher in the south and lower in the north， respectively. The ratio of cases in EEA and WEA was 3.79∶1， and that in SEA and NEA was 1.34∶1. The average annual incidence in EEA（0.14/100 000） was higher than that in WEA（0.06/100 000）， and the average annual incidence in SEA （0.17/100 000） was higher than that in NEA（0.07/100 000）. The prefectures with higher average annual incidences were concentrated in SEA， namely Xishuangbanna Dai Autonomous Prefecture（0.28/100 000）， Wenshan Zhuang and Miao Autonomous Prefecture （0.28/100 000） and Honghe Hani and Yi Autonomous Prefecture（0.22/100 000）. Conclusion： The border area where China， Laos and Vietnam meet should be considered as the key areas for rabies surveillance， prevention， and research in Yunnan Province. 

Investigation and Analysis on the Perceptions of Attitudes of Respiratory System Critically Ill Patients and Their Family Members towards Death

Hu Yongli, Dai Rufen, Yang Yanxia, Tan Zhengqiao

2023, 8(10):  95-100. 

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Objective： To investigate the perceptions of attitudes of respiratory system critically ill patients and their family members towards death， and provide reference for death education in this population. Methods： A total of 226 respiratory system critically ill patients and their family members from the People's Hospital of Dali Bai Autonomous Prefecture from May to October 2022 were randomly selected as investigation objects. Questionnaires and the Death Attitude Mapping Scale were used for investigation and analysis. Results： The death attitude of 226 respiratory system critically ill patients and their family members characterized by acceptance of death as a natural process， but also accompanied by psychological tendencies of avoidance and fear of death. There were significant differences in attitudes towards death among respiratory system critically ill patients and their family members with different characteristics. Conclusion： Death education should be conducted in different ways for respiratory system critically ill patients and their family members with different characteristics， aiming to establish a correct understanding of death and promote the value of cherishing and treasuring life.