Journal of Dali University

Study on the Compounds with α-Glucosidase Inhibitory Activity from Roots of Astragalus englerianus

Qiu Lin, Xiao Chaojiang, Dong Xiang, Jiang Bei

2017, 2(4): 1-5.

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Objective: To study the chemical components of Astragalus englerianus, and to explore the active compounds of α-
glucosidase's inhibiting from the roots of Astragalus englerianus. Methods: The compounds were isolated and purified by Rp-18,
Sephadex LH-20 and silica gel column chromatography. Their structures were identified by modern spectroscopy techniques.
The α -glucosidase's inhibiting experiment was performed by using enzyme inhibitor screening model with 4-nitrophenol α -
D-glucopyranoside（PNPG）as the substrate. Results: Six compounds were isolated from ethyl acetate fraction of methanol extract
of the roots of A. englerianus and identified as 1- O- hexadecanolenin（1）, 2,4'- dihydroxy- 4- methoxy dihydrochalcone（2）,
daucosterol（3）, 5α,6β- dihydroxy- daucosterol（4）,（3R）- vestitol- 7- O- glucoside（5）, and（2S,3S,4R,8E）- 2-［（2'R）- 2-
hydroxytetracosanoylamino］- 1,3,4- octadecanetriol- 8- ene（6）. All of these compounds were examined for their α- glucosidase
inhibitory activities. As a result, compound 2 showed significantly activity with the lower IC50 than the positive control, acarbose.
Compound 5 and its aglucon,（3R）-vestitol also showed some inhibitory activity. Conclusion: All of the compounds were isolated from
the roots of A. englerianus for the first time, and the flavonoids showed the better α-glucosidase inhibitory activity than the other
compounds.

Study on Trierpenoid Compositions of Medicinal Plants Triplostegia glandulifera

Zhang Zuzhen, Chen Yafeng, Wang Fusheng

2017, 2(4): 6-8.

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Objective: To study the chemical compositions of the Medicinal Plants Triplostegia glandulifera. Methods: The
compounds were isolated and purified by silica gel, Sephadex LH-20 and ODS column chromatography methods, and their structures
were identified by modern spectroscopy techniques. Results: Four trierpenoid compositions were isolated from ethyl acetate fraction of
the underground part of T. glandulifera and identified as 3β, 28-dihydroxy-ursane（1）, 3β, 23-Dihydroxyurs-12-en-28-oic-acid
（2）, α-Amirina（3）, and 3β-hydroxy-24-nor-urs-4（23）, 12-dien-28-oic acid（4）. Conclusion: Four trierpenoid compositions
were isolated from this genus for the first time.

Study on Chemical Components from n-butanol Fraction of Medicinal Plants Triplostegia glandulifera

Chen Yafeng, Zhang Zuzhen, Wang Fusheng

2017, 2(4): 9-11.

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Objective: To study the chemical constituents of n-butanol fraction of Triplostegia glandulifera, aiming at searching for
active components. Methods: The n-butanol fraction of T. glandulifera was separated by a combination of various chromatographied
including silica gel, AB- 8, ODS and LH- 20 gel column chromatography methods, and the structure were identified based on
spectroscopic analysis（1H NMR and 13C NMR）. Results: Five compounds were isolated from T. glandulifera and characterized as（3S,
4R,4aS,6S,7R,7aS）-Methyl 3,6-dihydroxy-7-methyloctahydrocyclopenta〔c〕pyran-4-carboxylate（1）, Methyl caffeate（2）,（+）-
Lariciresinol（3）, Sucrose（4）and Alyxialactone（5）. Conclusion: The five constituents were isolated from this genus for the first
time, and the compound 1 was isolated from natural products for the first time.

Identification of Polygonum multiflora and Its Adulterants based on ITS2 Barcode and
Chemical Fingerprint

Shang Feineng, Fang Hailan, Duan Baozhong

2017, 2(4): 12-15.

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Objective: To develop a rapid identification method to discriminate Polygonum multiflorum and its adulterants, and to
guarantee the quality and safety in medication. Methods: DNA barcode and high performance liquid chromatography（HPLC）were
used to compare the ITS2 barcode and the HPLC chemical fingerprint between Polygonum multiflorum and Polygonum denticulatum.
Results: The ITS2 length of Polygonum multiflorum and Polygonum denticulatum were 193 bp and 206 bp, respectively. The
intraspectific K2P genetic distance of Polygonum multiflorum was shorter than the intraspectific distance of Polygonum denticulatum.
Furthermore, there were obvious differences between their chemical fingerprints. Conclusion: DNA barcode and chemical fingerprint
both can be used to identify Polygonum multiflorum and its adulterants effectively.

Comparative Study on Six Kinds of Medicinal Plants in Tibetan Medicine "Dida" on Preventing Chronic
Hepatic Injury

Guo Yongqiang, Shen Lei, Yang Xiaoquan, Xia Conglong

2017, 2(4): 16-19.

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Objective: To compare the protective effect of six kinds of medicinal plants in Tibetan medicine "Dida" on chemical
hepatic injury. Methods: Carbon tetrachloride（CCl4）was used to cause chemical hepatic injury in mice to form the model group. The
serum hepatic injury index was used to detected the hepatoprotective effect of six medicinal plants of liver injury induced by serum
indicators to compare the effect of 6 species of medicinal plants. Results: Compared with the model group, six medicinal plants can
significantly reduce serum alanine transaminase（ALT）and aspartate aminotransferase（AST）activity, and increase total protein
（TP）and total bilirubin reduction（TBI）content. Compared with equivalent dose Swertia mileensis, Swertia chirayita（Roxb.ex Flemi）
Karsten, Swertia mussotii, Swertia punicea, Halenia elliptica, Saxifraga tangutica reduced ALT, AST, TBI and increased TP without
significant difference. Conclusion: Hepatoprotective effect on chemical hepatic injury of Swertia mileensis and other five kinds of
medicinal plants in "Dida" had no significant difference.

Effect of Breviscapin on the Efflux Activity of P-gp in Caco-2 Cells

Zhou Xuan, Cao Chang'e, Yang Jiao, Yang Meisong, Shao Mingyuan, Gao Yangyang, La

2017, 2(4): 20-23.

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Objective: To investigate the effect of breviscapin on the efflux activity of P-gp in Caco-2 cells. Methods: Cell survival
rate of Caco-2 cells with different breviscapin concentrations were measured by MTT assay. The BCA assay was used to determine the
total protein level of Caco-2 cells and the efflux activity of P-gp was determined by Rhodamine-123 assay after the incubation with
breviscapin. Results: The cell survival rate of Caco-2 cells was higher than 90% when the concentration of breviscapin was less than
577.95 μg/mL. The efflux activity of P-gp was increased by breviscapin（120 μg/mL, 240 μg/mL）in Caco-2 cells. The intracellular
accumulation of rhodamine-123 was increased and then decreased after the addition of rhodamine-123. After the incubation for 60
min with breviscapin（120 μg/mL, 240 μg/mL）, total protein level in Caco-2 cells was up-regulated 222.87%, 154.23% respectively.
Conclusion: Breviscapin can up-regulate total protein level and increase the efflux activity of P-gp in Caco-2 cells.

Study on the Mechanism of Seselopsis on Primary Dysmenorrhea Induced by Oxytocin in Mice

Zhou Qiwei, Guo Meixian, Yang Jiajing, Lu Ming, Jin Xuejun, Shen Lei, Liu Xiaobo

2017, 2(4): 24-27.

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Objective: To investigate the analgesic effect of ethanol extract from the seselopsis to the primary dysmenorrhea induced
by oxytocin in mice. Methods: A dysmenorrhea model combining diethylstilbestrol and oxytocin was used to observe the effect of
different concentrations of seselopsis ethanol extract and aspirin. About 1 h after the last medication, the uterine homogenate was
prepared, and the content of SOD activity, MDA, NO and Ca2 + were determined. Results: The ethanol extract from seselopsis could
significantly reduce the writhing response induced by oxytocin, which could significantly improve the activity of SOD, decrease the
content of MDA, increase NO and decrease the content of Ca2+（P＜0.05 or P＜0.01）. Conclusion: The ethanol extract of seselopsis
has obvious analgesic effect on primary dysmenorrhea in mice.

Research on Pinus yunnanensis Franch Pine Needle Polysaccharide's Effect of Scavenging Free Radical
and Anti-lipid Peroxidation

Li Yongfei, Fu Wenpeng , Ding Lu, Ma Zengyan, Yang Yongshou

2017, 2(4): 28-31.

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Objective: To study Pinus yunnanensis Franch pine needle polysaccharide's effect of scavenging free radical and antilipid
perxidation. Methods: DPPH was used to study the ability of scavenging free radicals of Pinus yunnanensis Franch pine needle
polysaccharide. TBARS was used to study the inhibition effect of Pinus yunnanensis Franch pine needle polysaccharide on MDA in the
mice liver tissue homogenate. The effect was compared with the antioxidation of vitamin C, and its anti lipid peroxidation ability was
evaluated as well. Results: Pinus yunnanensis Franch pine needle polysaccharide extract had certain scavenging effect on DPPH and
could inhibit MDA in the mice liver tissue lipid oxidation products of spontaneous generation. Conclusion: Pinus yunnanensis Franch
pine needle polysaccharide extract has scavenging effects on DPPH free radicals, and inhibition effect on rat liver homogenate
spontaneous lipid peroxidation, showing that Pinus yunnanensis Franch pine needles polysaccharide has good anti-oxidation action.

Antioxidant Effect of Flavonoids Compounds from Pine Needles of Pinus yunnanensis Franch

Fu Wenpeng, Li Yongfei, Yang Xiuyun, Yang Liu, Yang Yongshou

2017, 2(4): 32-35.

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Objective: To study the antioxidant activity of flavonoids compounds from pine needles of Pinus yunnanensis Franch and
to provide the basis for the utilization of pine needles of Pinus yunnanensis Franch. Methods: Extraction, purification and freezedrying
treatments were carried out with ethyl alcohol for dried and grinded pine needles of Pinus yunnanensis Franch; thus total
flavonoid extracts were obtained. DPPH was used to study the ability of scavenging free radicals of flavonoids from pine needles of
Pinus yunnanensis Franch. TBA was used to study the inhibiting effect of flavonoids from pine needles of Pinus yunnanensis Franch on
MDA in the mice liver tissue homogenate. Results: Flavonoids from pine needles of Pinus yunnanensis Franch had scavenging effect
on DPPH and could inhibit the generation of spontaneous liver homogenate lipid peroxidation MDA. Conclusion: The flavonoids from
pine needles of Pinus yunnanensis Franch had a strong anti-oxidant effect.

Protective Effect of Grape Seed Proanthocyanidin Extract on Lower Extremity Arteriosclerosis Obliterans

Lu Lei, Feng Chao, Cui Xuebing, Yang Jiwu, Qin Yan, Liu Rengui

2017, 2(4): 36-40.

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Objective: To investigate the protective effect of Grape Seed Proanthocyanidin Extract（GSPE） on lower extremity
arteriosclerosis obliterans（LEASO）, and to preliminarily explore its action mechanism. Methods: 30 male New Zealand rabbits were
randomly divided into three groups with 10 animals each to duplicate LEASO model. They were normal control group（CON group）,
LEASO model group, and GSPE group（0.5 g/kg）. The TC and ox-LDL in serum were assayed after operation for 4 th, 8 th and 12 th
week. At the end of 12th week, the content of SOD and MDA were detected. The right posterior femoral artery blood flow was detected
by color doppler ultrasound, and digital subtraction angiography（DSA）of the double posterior limbs in rabbit was conducted before
the operation and after 12th week. Results: Compared with CON group, rabbits of LEASO group had claudication and thanatosis was
found in both posterior limbs. GSPE group showed normal activity without thanatosis. Compared with LEASO group, GSPE group's
serum ox-LDL level decreased significantly at the end of 8th,12th week after operation（P＜0.05）. The activity of serum SOD raised
obviously while MDA decreased significantly（P＜0.05）. Compared with LEASO group, GSPE group showed higher PV of right
posterior superficial femoral artery under the detection of color doppler ultrasound （P＜0.01）. Detection of digital subtraction
angiography（DSA）showed that the distal vascular imaging of right posterior superficial femoral artery was good in GSPE group and
visible abundant collateral circulation was established. Conclusion: GSPE had a prominent protective effect on LEASO via removing
free radicals, reducing lipid peroxidation level, etc.

Analysis on Clinical Efficacy of Treating 198 Cases of Acute Cerebral Infarction TOAST Classification of Urokinase Intravenous Thrombolytic Therapy

Li Wenwu

2017, 2(4): 41-45.

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Objective: To review the effectiveness and safety of acute cerebral infarction TOAST classification with urokinase
intravenous thrombolytic therapy. Methods: The total effective rate of TOAST and the NIHSS before and after thrombolysis in acute
cerebral infarction were compared. Results: LAA, CE, SAO, SOE, SUE and total effective rate were 93.65%, 34.21%, 92.85%,
76.92%, 80.00%, respectively; NIHSS of LAA and SAO before and after thrombolytic therapy showed significant difference（P<0.05）;
the comparison of SOE, SUE, CE in the third week after thrombolytic therapy showed significant difference（P<0.05）. There was no
significant difference in NIHSS among different subtypes of TOAST before and after thrombolytic therapy（P>0.05）. There was
significant difference in total effective rate and bleeding rate between LAA and SAO in different time windows（P<0.05）. Conclusion:
The dose of acute cerebral infarction TOAST classification of urokinase thrombolytic therapy should be individualized.

Clinical Observation of Treatment for Cervical Lymphoid Tuberculosis by Ultrasonic Therapeutic
Apparatus

Zhao Xiao, Fan Zhijian, Wan Rong

2017, 2(4): 46-48.

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Objective: To observe the treatment efficacy of cervical lymphoid tuberculosis by ultrasonic therapeutic apparatus.
Methods: 77 patients with cervical lymphoid tuberculosis were randomly divided into treatment group（47 cases）and control group
（30 cases）. The control group was only treated by anti-tuberculosis chemotherapy. The efficacy was compared between the two groups,
and the lymph node size of treatment group was compared in different periods. Results: The rate of efficiency of treatment group was
higher than the control group, and there were significant differences（P＜0.05）. The highest efficiency was on the 28th day in
treatment group. The efficacy of treatment was significant difference by comparing 7th day with 28th day（P＜0.01）, and the same
result was between 14th day and 28th day（P＜0.05）. There was no significant difference of the efficacy between 21st day and 28th
days（P＞0.05）. Conclusion: Treatment for cervical lymphoid tuberculosis by ultrasonic therapeutic apparatus was safe and effective,
and the course of treatment is appropriate in the 21-28 days.

On the Sternoclavicuar Hook Plate for the Treatment of Sternoclavicular Joint Dislocation

He Ning, Li Chao, Zhao Jianbo,Yin Kun

2017, 2(4): 49-51.

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Objective: To explore the clinical effect of the sternoclavicuar hook plate for the treatment of sternoclavicular joint
dislocation. Methods: 5 cases of dislocation of sternoclavicular joint, and 1 case of dislocation of sternoclavicular joint combined with
fracture of the sternal end clavicle in the Department of Orthopaedics from March 2010 to October 2015 were operated with
sternoclavicuar hook plate fixation. Results: All 6 patients had been followed-up for 12-16 months, with the result 4 cases were in
excellent recovery, 1 case was good, 1 case was acceptable, and the the rate of excellent and good was 83%. The clinical effect is
satisfied. Conclusion: The sternoclavicuar hook plate can fix dislocation of sternoclavicular joint firmly. It can fix sternoclavicular joint
dislocation combined with fracture of the sternal end clavicle, and can keep the jiggle of the sternoclavicular joint, which is a
satisfactory curative effect of internal fixation.

Clinical Research of Thyroid Malignant Tumor among Han and Bai Nationality in Dali

Wang Kai, Kang Siru, Guan Yunfei, Tan Yunbo

2017, 2(4): 52-55.

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Objective: To explore the clinical and pathological features of Han and Bai nationality patients with thyroid malignancy
tumor treated in Yunnan Provincial Fourth People's Hospital. Methods: A total of 198 clinical cases of ethnic patients with thyroid
malignancy tumor who treated in The Fourth People's Hospital of Yunnan from January 2011 to December 2015 were retrospectively
analyzed. Results: The cases of Han were 140（70.71%）and the Bai were 58（29.29%）. So ethnic composition ratio between cases
and local population has a very significant difference（P<0.05）; The rank of the rate of pathological type is papillary thyroid carcinoma,
follicular thyroid carcinoma, medullary thyroid carcinoma, undifferentated thyroid carcinoma in order. The patients of more than 45
years old and under 45 years old have no difference in malignant degree（P>0.05）. Conclusion: The incidence of Yunnan Han and
Bai ethnic patients with thyroid malignancy tumor treated in The Fourth People's Hospital of Yunnan has increased within five years,
with nationality and regional difference. According to the ratio analysis, the morbidity of Han nationality is significantly higher than the
Bai cases.

Effect of Intensive Silver Needle Combined with Stellate Ganglion Block on Cervical Vertigo

Li Junfeng, Xiong Zhihong

2017, 2(4): 56-58.

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Objective: To investigate therapeutic effect of intensive silver needle combined with stellate ganglion block（SGB）on
cervical vertigo. Methods: 120 patients of cervical vertigo were randomly divided into two groups. Group I used intensive silver needle
treatment combined with SGB, group Ⅱ used SGB only. Visual Analogue Scale （VAS）, evaluation of therapeutic effects and
recurrence rate were recorded at one week before treatment, one week and six months after treatment. Results: The results
demonstrated that: both groups had significantly improved in VAS pain score after treatment（P<0.05）. The VAS rate of group I was
obviously inferior to group Ⅱ after treatment. The excellent and good rate of group I was 100%; group Ⅱ was 70%-80%. After one
year's follow-up, it showed that: 12 cases relapsed in group Ⅱ, while zero case in group I. Conclusion: It suggests that this method is
characterized by the advantages of stable efficacy, high safety, low adverse reactions in the treatment of cervical vertigo.

Analysis on Epstein-Barr Virus Infection in AIDS-related Diffuse Large B-cell Lymphoma

Gao Bo, Sun Jingjing, Duan Yuexun, Deng Gang, Yang Qian, Wang Lin, Pan Yun

2017, 2(4): 59-62.

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Objective: To analyze the Epstein-Barr Virus（EBV）infection and discuss the role of EBV in AIDS/HIV-related diffuse
large B-cell lymphoma（HIV-DLBCL）. Methods: 20 cases of HIV-DLBCL were collected as experiment group. 5 cases of non-HIVDLBCL,
4 cases of HIV-reactive hyperplasia（HIV-RH）and 5 cases of non-HIV-RH were collected as control group. The expression
of EBER（EBV-encoded RNA）was detected by in-situ nucleic acid hybridization. Results: The total positive expression rate of
EBER in HIV-DLBCL and in non-HIV-DLBCL was 30%（6/20）and 40%（2/5）, respectively. EBER was negative in both HIV-RH
and non-HIV-RH. Conclusion: EBV infection was involved in tumorigenesis of part of DLBCLs, but it needs to be further studied on
whether EBV functions differently in HIV-DLBCL and non-HIV-DLBCL or not.

Laboratory Examination and Clinical Analysis of 38 Cases of Multiple Myeloma

Xu Wenyan, Liu Qiuhong, Hu Lirong

2017, 2(4): 63-65.

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Objective: To summarize and analyze the characteristic of laboratory of Multiple Myeloma（MM）, and to improve the
understanding of MM for avoiding the missed diagnosis and misdiagnosis. Methods: Retrospective analysis was done in the laboratory
characteristic and clinical feature of 38 cases of diagnosed MM. Results: Among the 38 cases, 29 cases had anemia, 18 cases had
ostealgia, 5 cases had renal failure, 3 cases had RTI, and 2 cases had gastritis. Anemia and ostealgia were the most common ones. The
rate of plasmacyte was high in the examination of marrow cell with diversity and visible dual-core or myeloma cells could be found. Xray
showed the multiple moth- eaten and punched- out lesions in bones with low density, blur edge and pathological fracture.
Conclusion: In the practical work, inspectors should enhance the understanding of MM, be clear about it features, and be able to
analyze comprehensively about the abnormal laboratory results for timely detection and diagnosis of multiple myeloma.

Study on Two Preparation Methods of Whole Blood Hemolytic Blood in Detection of HbA1c

Lyu Jingliang

2017, 2(4): 66-68.

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Objective: To compare the results of two preparation methods of whole blood hemolytic blood in detection of HbA1c and
to further prove the necessity of wiping the blood on suction head before detecting. Methods: 37 cases in physical examination for
HbA1c detection in Kungang Hospital as the samples. The mean value of three detection results had been used in statistical analysis.
Results: The comparison of the mean value of Hb and HbA1c showed significant differences in statistic（P＜0.05）, while the
comparison of the mean value of HbA1c% had no significant differences in statistic（P＞0.05）. Conclusion: There is no necessity of
wiping the blood on suction head preparing whole blood hemolytic blood in the detection of HbA1c.

Clinical Application Analysis of Percutaneous Renal Biopsy Guided by Ultrasound

Song Yu, Liu Qingqing

2017, 2(4): 69-71.

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Objective: To explore the clinical application value of percutaneous renal biopsy guided by ultrasound. Methods:
Retrospective analysis was done among 182 cases of percutaneous renal biopsy guided by ultrasound from April 2012 to June 2012. Its
success rate, complication rate, pathological types of distribution and clinical diagnosis of correction were analyzed as well. Results:
Materials of puncture success rate was 100%, mild postoperative complication rate was 6.6%, no serious complications occurred. The
original diagnosis of postoperative correction rate was 22.53%. According to the statistics, postoperative primary glomerular disease
incidence rate was higher than secondary glomerular disease. IgA nephropathy in primary glomerular disease had the highest
incidence, accounting for 45.62%, followed by lupus nephritis, accounting for 36.45%. Conclusion: Percutaneous renal biopsy is a
safe and effective nephropathy auxiliary diagnosis methods. Pricking the left or the right kidney reached the same result, and the
incidence of complications of right and left renal biopsy had no difference. Incidence rate of primary glomerular disease is the highest,
among which IgA nephropathy is the most common one. And the probability of men suffering from kidney disease is higher than women.

Application Value of Obstertric Ultrasound Screening System in Prenatal Diagnosis

Xie Dan, Liu Qingqing

2017, 2(4): 72-74.

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Objective: To explore the application of obstetric ultrasound screening system in prenatal diagnosis. Methods: Screening
systemic in 660 cases in the middle of the pregnancy were retrospectively analyzed. The diagnosis of fetal abnormalities by
ultrasonography was compared with clinical diagnosis. Results: Obstetric ultrasound screening system had high detection rate in fetal
abnormality, and the diagnostic coincidence rate was 99%. Conclusion: Obstetric ultrasound screening system for prenatal diagnosis
has the important clinical application value in detection, which can significantly increase the detection rate of fetal abnormalities,
effectively reduce birth defects.

Epidemiological Analysis on Hand-foot-mouth Disease in Yuanjiang County from 2009 to 2014

Li Wenya, Wang Zhigang, Yang Ren, Liu Dongqing, Ran Xuejun

2017, 2(4): 75-78.

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Objective: To understand the prevalent characteristics of hand-foot-mouth disease in Yuanjiang County from 2009 to
2014, and to provide scientific basis for the disease control and prevention. Methods: SPSS 17.0 statistical software was used to
analyze the epidemiology and etiology of hand-foot-mouth disease data based on the online report of Yuanjiang County from 2009 to
2014. Results: A total of 4 060 cases of hand- foot- mouth were reported in Yuanjiang County from 2009 to 2014, the average
incidence was 330.0/105, and the epidemic curve showed a trend of "M" type. Morbidity peak period has the tendency of shifting from
the autumn to winter and spring, appearing "twin peaks" type distribution. The hand- foot- mouth disease cases were mainly
concentrated in Lijiang Town, Ganzhuang Streets and Manlai Town. Lijiang Town was the top at the number occurred of hand-footmouth
disease each year. The incidence has difference among high, medium and low altitude areas（χ2=1 581.20, P＜0.01）. The
highest incidence rates were in low altitude （533.8/105）, and high altitude area had the lowest incidence rates （89.6/105）.
Conclusion: The horizontal and vertical characteristics of hand-foot-mouth disease should be combined in prevention and control of
the disease. Especially the key areas and key crowd should be strengthened on early warning, prevention and control.

Nursing Care on Patients with Transurethral Resection of Bladder Tumor in the Perioperative Period

Yuan Yicun, Deng Huifang

2017, 2(4): 79-81.

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Objective: To summarize the nursing care of patients with TUR-BT surgery in the perioperative period. Methods: The
clinical data were retrospectively analyzed about 238 patients with TUR- BT surgery. Results: A group of patients successfully
completed surgery and went through perioperation period smoothly, with 129 cases healed completely well, 99 cases had been getting
better, 10 cases had no effect, and the total cure rate was 95.8%. Conclusion: Improving the preoperative and postoperative nursing is
the key to the success of surgery using TUR-BT.

Application and Effect of Clinical Nursing Pathway in COPD Patient

Dong Jiao, Zhao Guifeng

2017, 2(4): 82-84.

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Objective: To investigate the application and effect of clinical nursing pathway（CNP）on COPD patients. Methods: 76
COPD patients who were in hospital from May to November in 2015 were divided into observation group and control group with 38
patients in each group. The observation group received the nursing mode of clinical nursing pathway, while the control group using the
traditional mode. Results: The patient's health knowledge and patient's satisfaction to medical care services of observation group were
better than the control group（P<0.05）and the average length of hospital stay in the observation group were significantly lower than the
control group（P<0.05）. Conclusion: The working mode of clinical nursing pathway increased the COPD patients' health education
comprehensively, improved the patients' satisfaction to medical care services and reduced the average length of hospital stay. It is
worth of popularity in clinical care.

Nursing Experience of 20 Cancer Patients Using Implantable Venous Transfusion Port

Li Huamei, Shi Juan

2017, 2(4): 85-88.

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Objective: To investigate the implantable venous port application effect of cancer patients and nursing experience.
Methods: 20 patients with tumors implanted venous port care were analyzed. Results: Among 20 patients, 1 case got removal due to
skin damage at the site of port pocket, and 1 case was required removal due to slow infusion rate with no aspirated blood, and other 18
patients continued to use. Conclusion: The implantable venous port helps establish a good venous access for cancer patients'
chemotherapy and nutritional support, reduces pain in repeated puncture and vein injury, reduces restrictions in daily life, offers
convenience in medication treatment, and improves the living quality.

Investigation on the Cognition of Nursing Staff on the Factors Influencing the Safety of Patients

Dong Fangping, Yang Xueyan, Yang Yuan, Shu Qiaoling, Li Ting

2017, 2(4): 88-91.

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Objective: To explore the factor of cognition of nursing staff in influencing the safety of patients in The First People's
Hospital of Dali and to provide guidance for further improving hospital nursing safety management work . Methods: Clinical nursing
staff patient safety culture assessment questionnaire was used among 320 hospital nursing staff. Results: The scoring of eight
dimensions of patient safety factors are listed below: Hospital management support is（4.520 ±0.118）, the head nurse participation is
（4.515 ±0.055）, the nurse executive force is（3.010±0.210）, team work is（4.292±0.103）, open communication is（4.156±0.113）,
continuous improvement is（4.530±0.138）, punitive feeling is（3.317±0.180）, adverse event report is（2.032±0.116）. There was no
statistically significant difference comparing different dimensions within the group. Conclusion: Most of nurses in The First People's
Hospital of Dali had higher secondary level cognitive status of patient safety culture, and five of them needs further improvement in
"nurses' execution", "punitive feeling", and "adverse event reporting".

The Early Nursing of Acute Myocardial Infarction Patients

Wu Yongli

2017, 2(4): 92-93.

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Objective: To establish the emergency nursing for acute myocardial infarction patients and to provide the guidance for
nursing and prevention of acute myocardial infarction. Methods: Retrospective analysis and summary of 39 cases of myocardial
infarction in The First Affiliated Hospital of Dali University were done. Results: 4 cases transferred to other hospital, 6 patients
discharged automatically, 6 cases died, 23 cases recovered. No complications occurred during hospitalization. Conclusion: With the
treatment and close observation, timely and effective comprehensive nursing can help in reducing the mortality of myocardial infarction
patients and improving the nursing quality and patients satisfaction rate, which is worthy of clinical application.

Evaluation of the Comprehensive Skill Strengthening Effect of Nursing Undergraduates before Internship

Lu Yumiao, Yan Wenjing

2017, 2(4): 94-97.

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Objective: To evaluate the teaching effect of nursing comprehensive skills strengthening for undergraduates before
internship, to reflect the teaching process and explore the teaching methods. Methods: Questionnaire survey was conducted after
nursing skill strengthening among undergraduates of 2013. Results: Students think that it's very necessary to train the following items:
intravenous infusion, injection technique, cardiopulmonary resuscitation（CPR）, aseptic technique, breathing machine. The training
can greatly improve students' comprehensive ability in language, communication, problem solving, team work, clinical thinking,
nursing techniques, overall nursing ability and coping capacity. Conclusion: Skill tests and professional knowledge strengthening can
improve the skills and lay a foundation for the clinical internship.

On the Practice of PBL Teaching Mode in Experiment of Preventive Medicine in International Students of
Dali University

Yuan Zhiqiong, Li Yuncheng, Gao Chunyan, Zhang Xiaoyun, Shen Yuanying

2017, 2(4): 98-100.

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Objective: To study the PBL teaching mode for improving the effect in preventive medicine experiment teaching of
international students, to explore suitable mode for international student education, and to improve their level of mastering knowledge
with preventive medicine. Methods: A cluster stratified sample of all international medical students of 2005-2011 in Dali University
were investigated. The traditional LBL teaching method was used in 207 students of 2005 to 2008, while the PBL teaching method was
used in 251 students of 2009 to 2011 for evaluating the preventive medicine experiment results. Results: The preventive medicine
experiment grades different grade students of under the same teaching methods had statistical difference（P=0.000）. The grades in
different teaching modes had statistical difference（t=21.063, P=0.000）. Conclusion: Comparing with traditional LBL teaching mode,
the preventive medicine experiment grades of international students were improved significantly under the PBL teaching mode.

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